Sp slip absorb plasma apolipoproteins a1 e and j consequently exposing receptor binding domain of apolipoproteins to achieve brain targeted delivery doxorubicin loaded sp slip sp slip dox show significant enhancement of brain distribution and anti brain cancer effect in comparison to doxorubicin loaded plain liposomes sp slip preserve functions of the absorbed human plasma apoe and the corona mediated targeting strategy works in sp modified plga nanoparticles the present study may . Brain targeted drug delivery systems a focus on nanotechnology and nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers the book discusses key points in the development of brain targeted drug delivery summarizes available strategies and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems as the brain is the most important organ in the human body and disorders of the central nervous . Drug delivery to the brain is the process of passing therapeutically active molecules across the blood brain barrier for the purpose of treating brain maladies this is a complex process that must take into account the complex anatomy of the brain as well as the restrictions imposed by the special junctions of the blood brain barrier. To achieve successful delivery an understanding of the major structural enzymatic and active transport aspects related to the bbb and of the issues related to lipophilicity and its role in cns entry is critical during the last years considerable effort was focused in the field of brain targeted drug delivery. Brain targeted drug delivery to the brain is valuable in the diseases of brain alzheimers diseases meningitis brain abscess epilepsy multiple sclerosis neuromylitis optica sleeping
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